First Nations people have long called for greater understanding and action to prevent suicide in their communities. Suicide is deeply complex, shaped by the ongoing impacts of colonisation, intergenerational trauma, systemic racism, and socioeconomic marginalisation. These experiences intersect across the life course and are influenced by cultural, historical, and structural contexts. The aim of this paper is to explore the existing literature, data, and lived experience relating to suicide prevention for First Nations people. The report brings together community knowledge, research and policy, to highlight what is already known about protective factors, particularly the roles of culture, connection, self-determination and healing. Despite this knowledge, there remains a significant gap between evidence and action. Addressing this requires long-term, adequately resourced, and culturally safe approaches that are community-led and strengths-based. Importantly, governments and services must commit to implementing what is already known and invest in holistic, culturally responsive care that meets the needs and aspirations of First Nations peoples and communities.