Psychological practice emphasises the importance of using the best available evidence to ensure accountability and promote positive outcomes for individuals and communities. These expectations are critical for community trust; however, without adequate consideration of broader processes of knowledge production, this focus can marginalise populations and perpetuate health inequities, such as those experienced by Aboriginal and Torres Strait Islander communities. Considering new professional practice expectations in psychology, this article examines the foundations of these standards and how they might be effectively implemented. We present a conceptual exploration of empirical and constructionist perspectives on evidence and introduce guidelines for practice-based evidence (PBE), including theoretical and practical implications to yield the best available evidence that guides culturally safe practice when working with Aboriginal and Torres Strait Islander peoples.